I feel like Entocort is the biggest waste of time. After 3.5 weeks I have noticed no real improvement. At about week two I had a little relief but it subsided quickly. Both my new doctor and I are trying everything possible to avoid prednisone, since I have had miserable experiences with it in the past. Since my crohn's is mainly in my ileum and Entocort is specifically targeted towards the ileum we thought we would give it a try. Since it hasn't worked, the typical next course of action would be prednisone, but I'm really pushing for Humira, Remicade or another biologic.i know they come with many side effects, but I absolutely refuse to subject my body to prednisone. The weight gain, acne, joint pain are bad enough as it is, but prednisone also triggers many psychological side effects in me, perpetuating my anxiety and PTSD through the roof. Monday can't come soon enough. I am really trying to follow my training schedule for upcoming runs, but right now with zero energy, and crazy bathroom issues, I've had to take a few steps back, which is so frustrating. Fingers crossed